Analysis of Individual Social-ecological Mediators and Moderators and Their Ability to Explain Effect of a Randomized Neighborhood Walking Intervention

Abstract Background Using data from the SHAPE Pumps trial, a randomized 6-month neighborhood-based intervention designed to increase walking activity among older adults, this study identified and analyzed social-ecological factors mediating and moderating changes in walking activity.Methods Three potential mediators (social cohesion, walking effica

read more

First-episode mania after COVID-19: A case series in Iran

BackgroundIncreasing reports of manic episodes in patients during acute infection with COVID-19 have been documented since the pandemic began, including individuals without a previous personal or family history of bipolar disorder.As infections and autoimmunity have putative roles in bipolar disorder, we aimed to document the clinical presentations

read more

Design optimization for an integrated tri-generation of heat, electricity, and hydrogen powered by biomass in cold climates

For green hydrogen energy systems driven by renewables, despite the complexities in design and operations, uncertainties related to availability of infrastructures or seasonality of Pumps resources are significant as well as the uncertainties in technical side such as adoption of technologies for energy generation, conversion, and storage.Such unce

read more

Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen.

BackgroundIn breast cancers, only a minority of patients fully benefit from the different chemotherapy regimens currently in use.Identification of markers that could predict the response to a particular regimen would thus be critically important for patient care.In cell lines or animal models, tumor protein p53 (TP53) plays a critical role in modul

read more